The m⁶A-related gene signature for predicting the prognosis of breast cancer.

ABSTRACT: N6-methyladenosine (m⁶A) modification has been shown to participate in tumorigenesis and metastasis of human cancers. The present study aimed to investigate the roles of m⁶A RNA methylation regulators in breast cancer. We used LASSO regression to identify m⁶A-related gene signature predicting breast cancer survival with the datasets downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA). RNA-Seq data of 3409 breast cancer patients from GSE96058 and 1097 from TCGA were used in present study. A 10 m⁶A-related gene signature associated with prognosis was identified from 22 m⁶A RNA methylation regulators. The signature divided patients into low- and high-risk group. High-risk patients had a worse prognosis than the low-

SUBMITTER: Zhong S 

PROVIDER: S-EPMC8183431 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature