Development and validation of risk and prognostic nomograms for bone metastases in Chinese advanced colorectal cancer patients.

ABSTRACT:

Background

Bone metastases (BM) from colorectal cancer (CRC) are often accompanied by extraosseous metastases, resulting in a dismal prognosis. The present study aimed to determine the risk factors for BM in metastatic CRC (mCRC) and the prognostic factors for CRC patients with BM.

Methods

The study was based on a training cohort of 214 mCRC patients (of which, 101 patients had BM) from our center, and a validation cohort of 511 mCRC patients (of which, 173 patients had BM) from another institute. Risk and prognostic nomograms for BM were developed using univariate and multivariate analyses. The goodness of fit, discrimination, and calibration performance of the nomograms were assessed by R², concordance statistics (C-statistics), and the calibration curve. The re

SUBMITTER: Wang N 

PROVIDER: S-EPMC8184451 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature