Dataset Information

Development and validation of risk and prognostic nomograms for bone metastases in Chinese advanced colorectal cancer patients.

ABSTRACT:

Background

Bone metastases (BM) from colorectal cancer (CRC) are often accompanied by extraosseous metastases, resulting in a dismal prognosis. The present study aimed to determine the risk factors for BM in metastatic CRC (mCRC) and the prognostic factors for CRC patients with BM.

Methods

The study was based on a training cohort of 214 mCRC patients (of which, 101 patients had BM) from our center, and a validation cohort of 511 mCRC patients (of which, 173 patients had BM) from another institute. Risk and prognostic nomograms for BM were developed using univariate and multivariate analyses. The goodness of fit, discrimination, and calibration performance of the nomograms were assessed by R², concordance statistics (C-statistics), and the calibration curve. The results were internally validated using bootstrap resampling in the training cohort, and externally validated in the validation cohort.

Results

The novel BM risk nomogram comprised seven variables [degree of tumor differentiation, N-stage, serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA), liver metastasis, and lung metastasis]. It showed good performance, with an R² of 0.447 and a C-statistic of 0.846 [95% confidence interval (CI), 0.793 to 0.898] in the training cohort, and an R² of 0.325 and a C-statistic of 0.792 (95% CI, 0.750 to 0.834) in the validation cohort. The optimal cutoff value to identify individuals at low or high risk was 56% probability, with a sensitivity of 71.3% and a specificity of 89.4%. The prognostic nomogram included five factors (tumor differentiation, number of extra-BM organs, number of BM lesions, ALP, and LDH), and had an R² of 0.284 and a C-statistic of 0.723 (95% CI, 0.657 to 0.789) in the training set. This nomogram was externally validated in the validation cohort, with an R² of 0.182 and a C-statistic of 0.682 (95% CI, 0.638 to 0.726).

Conclusions

The developed and validated risk and prognostic nomograms showed good performance for predicting the occurrence of BM in mCRC as well as the prognosis of CRC patients with BM. The risk nomogram can be used as a cost-effective preliminary screening tool prior to bone scanning.

SUBMITTER: Wang N

PROVIDER: S-EPMC8184451 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Development and validation of risk and prognostic nomograms for bone metastases in Chinese advanced colorectal cancer patients.

Wang Nan N Liu Fangqi F Xi Wenqi W Jiang Jinling J Xu Yun Y Guan Bingjie B Wu Junwei J Zhou Chenfei C Shi Min M Zhu Zhenggang Z Xu Ye Y Liu Jing J Zhang Jun J

Annals of translational medicine 20210501 10

<h4>Background</h4>Bone metastases (BM) from colorectal cancer (CRC) are often accompanied by extraosseous metastases, resulting in a dismal prognosis. The present study aimed to determine the risk factors for BM in metastatic CRC (mCRC) and the prognostic factors for CRC patients with BM.<h4>Methods</h4>The study was based on a training cohort of 214 mCRC patients (of which, 101 patients had BM) from our center, and a validation cohort of 511 mCRC patients (of which, 173 patients had BM) from a ...[more]

PMID: 34164509

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Dataset Information

Development and validation of risk and prognostic nomograms for bone metastases in Chinese advanced colorectal cancer patients.

Background

Methods

Results

Conclusions

Publications

Development and validation of risk and prognostic nomograms for bone metastases in Chinese advanced colorectal cancer patients.

Similar Datasets

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