Vapor-phased fabrication and modulation of cell-laden scaffolding materials.

ABSTRACT: Bottom-up approaches using building blocks of modules to fabricate scaffolds for tissue engineering applications have enabled the fabrication of structurally complex and multifunctional materials allowing for physical and chemical flexibility to better mimic the native extracellular matrix. Here we report a vapor-phased fabrication process for constructing three-dimensional modulated scaffold materials via simple steps based on controlling mass transport of vapor sublimation and deposition. We demonstrate the fabrication of scaffolds comprised of multiple biomolecules and living cells with built-in boundaries separating the distinct compartments containing defined biological configurations and functions. We show that the fabricated scaffolds have mass production potential. We demonstrate o

SUBMITTER: Wu CY 

PROVIDER: S-EPMC8184845 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature