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The impact of coronavirus disease 2019 (COVID-19) response on central-line-associated bloodstream infections and blood culture contamination rates at a tertiary-care center in the Greater Detroit area.

ABSTRACT: We conducted a comparative retrospective study to quantify the impact of coronavirus disease 2019 (COVID-19) on patient safety. We found a statistically significant increase in central-line-associated bloodstream infections and blood culture contamination rates during the pandemic. Increased length of stay and mortality were also observed during the COVID-19 pandemic.

SUBMITTER: LeRose J

PROVIDER: S-EPMC8185425 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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The impact of coronavirus disease 2019 (COVID-19) response on central-line-associated bloodstream infections and blood culture contamination rates at a tertiary-care center in the Greater Detroit area.

LeRose Jennifer J Sandhu Avnish A Polistico Jordan J Ellsworth Joe J Cranis Mara M Jabbo Lavina L Cullen Lori L Moshos Judy J Samavati Lobelia L Chopra Teena T

Infection control and hospital epidemiology 20201120 8

We conducted a comparative retrospective study to quantify the impact of coronavirus disease 2019 (COVID-19) on patient safety. We found a statistically significant increase in central-line-associated bloodstream infections and blood culture contamination rates during the pandemic. Increased length of stay and mortality were also observed during the COVID-19 pandemic. ...[more]

PMID: 33213553

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Project description:The study examines the increasing use of organic soil amendments (OSA) due to declining soil fertility and the high cost of synthetic fertilizers, alongside growing concerns about microplastics (MPs) accumulating in soil, which negatively impact soil, crop, and food quality. This research assessed the presence and characteristics of microplastics in Municipal Solid Waste Composts (MSWC) and dry sewage sludge (DSS) within the Greater Accra Metropolitan Area (GAMA) of Ghana. The study analyzed two sources of MSWC (MSWC 1 and MSWC 2) and two sources of DSS (Sludge 1 and Sludge 2), with five samples each, for microplastic concentrations. A reference soil sample, collected from a depth of 0-25 cm, was also tested. The microplastics were extracted using acid digestion (30 % H2O2 at 70 °C), density separation with a ZnCl2 solution, and vacuum filtration. Results revealed that Sludge 1 had the highest concentration of microplastics (4316 ± 968 MP kg-1), followed by MSWC 1 (3572 ± 1196 MP kg-1), MSWC 2 (3104 ± 418 MP kg-1), and Sludge 2 (2024 ± 562 MP kg-1). The soil sample had the lowest concentration of 232 ± 62 MP kg-1. Statistical analyses (Kruskal Wallis and Dunn's multiple comparisons) showed significant differences (p < 0.05) in microplastic concentrations among the samples. The composition of microplastic polymers varied among the samples. The soil sample predominantly contained cellophane (91.67 %) and polyvinyl propionate (8.33 %). MSWC 1 contained urethane alkyd (31.11 %), polyethylene (26.67 %), and polyester (20 %), while MSWC 2 had polyethylene (24.10 %), polyester (20.48 %), cellophane (18.07 %), and polypropylene (15.66 %). Sludge 1 was dominated by polyethylene (35.29 %), polypropylene (30.25 %), cellophane (15.13 %), and urethane alkyd (11.76 %), whereas Sludge 2 mainly contained polyester (42.86 %), cellophane (23.21 %), urethane alkyd (21.43 %), and polyethylene (12.50 %). Microplastics were prevalent in the MSWC and sewage sludge which were obtained from the GAMA, with significantly higher concentrations than those in the soil samples. Further research is needed to develop strategies to mitigate microplastic pollution in OSAs to improve soil health.

Project description:BackgroundRacial segregation is linked to poorer neighborhood quality and adverse health conditions among minorities, including worse cancer outcomes. We evaluated relationships between race, neighborhood social disadvantage, and cancer survival.MethodsWe calculated overall and cancer-specific survival for 11,367 non-Hispanic Black (NHB) and 29,481 non-Hispanic White (NHW) individuals with breast, colorectal, lung, or prostate cancer using data from the Metropolitan Detroit Cancer Surveillance System. The area deprivation index (ADI) was used to measure social disadvantage at the census block group level, where higher ADI is associated with poorer neighborhood factors. Associations between ADI and survival were estimated using Cox proportional hazards mixed-effects models accounting for geographic grouping and adjusting for demographic and clinical factors.ResultsIncreasing ADI quintile was associated with increased overall mortality for all four cancer sites in multivariable-adjusted models. Stratified by race, these associations remained among breast (NHW: HR = 1.16, P < 0.0001; NHB: HR = 1.20, P < 0.0001), colorectal (NHW: HR = 1.11, P < 0.0001; NHB: HR = 1.09, P = 0.00378), prostate (NHW: HR = 1.18, P < 0.0001; NHB: HR = 1.18, P < 0.0001), and lung cancers (NHW: HR = 1.06, P < 0.0001; NHB: HR = 1.07, P = 0.00177). Cancer-specific mortality estimates were similar to overall mortality. Adjustment for ADI substantially attenuated the effects of race on mortality for breast [overall proportion attenuated (OPA) = 47%, P < 0.0001; cancer-specific proportion attenuated (CSPA) = 37%, P < 0.0001] prostate cancer (OPA = 51%, P < 0.0001; CSPA = 56%, P < 0.0001), and colorectal cancer (OPA = 69%, P = 0.032; CSPA = 36%, P = 0.018).ConclusionsArea-level socioeconomic disadvantage is related to cancer mortality in a racially diverse population, impacting racial differences in cancer mortality.ImpactUnderstanding the role of neighborhood quality in cancer survivorship could improve community-based intervention practices.

Dataset Information

The impact of coronavirus disease 2019 (COVID-19) response on central-line-associated bloodstream infections and blood culture contamination rates at a tertiary-care center in the Greater Detroit area.

Publications

The impact of coronavirus disease 2019 (COVID-19) response on central-line-associated bloodstream infections and blood culture contamination rates at a tertiary-care center in the Greater Detroit area.

Similar Datasets

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