Rapamycin Improves the Response of Effector and Memory CD8⁺ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi.

ABSTRACT: Deficiency in memory formation and increased immunosenescence are pivotal features of Trypanosoma cruzi infection proposed to play a role in parasite persistence and disease development. The vaccination protocol that consists in a prime with plasmid DNA followed by the boost with a deficient recombinant human adenovirus type 5, both carrying the ASP2 gene of T. cruzi, is a powerful strategy to elicit effector memory CD8⁺ T-cells against this parasite. In virus infections, the inhibition of mTOR, a kinase involved in several biological processes, improves the response of memory CD8⁺ T-cells. Therefore, our aim was to assess the role of rapamycin, the pharmacological inhibitor of mTOR, in CD8⁺ T response against T. cruzi induced by hetero

SUBMITTER: Moraschi BF 

PROVIDER: S-EPMC8191465 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature