Necroptosis protects against exacerbation of acute pancreatitis.

ABSTRACT: The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of cell death and is involved in inflammatory conditions, the roles of necroptosis in acute pancreatitis (AP) remain unclear. In the current study, we administered caerulein to Ripk3- or Mlkl-deficient mice (Ripk3^-/- or Mlkl^-/- mice, respectively) and assessed the roles of necroptosis in AP. We found that Ripk3^-/- mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice. Consistently, Mlkl^-/- mice were more susceptible

SUBMITTER: Boonchan M 

PROVIDER: S-EPMC8192754 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature