Ontology highlight
ABSTRACT:
SUBMITTER: Vezina-Dawod S
PROVIDER: S-EPMC8201483 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Vezina-Dawod Simon S Angelbello Alicia J AJ Choudhary Shruti S Wang Kye Won KW Yildirim Ilyas I Disney Matthew D MD
ACS medicinal chemistry letters 20210302 6
RNA contributes to disease pathobiology and is an important therapeutic target. The downstream biology of disease-causing RNAs can be short-circuited with small molecules that recognize structured regions. The discovery and optimization of small molecules interacting with RNA is, however, challenging. Herein, we demonstrate a massively parallel one-bead-one-compound methodology, employed to optimize the linker region of a dimeric compound that binds the toxic r(CUG) repeat expansion [r(CUG)<sup> ...[more]