Critical role of the CD44^lowCD62L^low CD8⁺ T cell subset in restoring antitumor immunity in aged mice.

ABSTRACT: CD8⁺ T cells play a central role in antitumor immune responses that kill cancer cells directly. In aged individuals, CD8⁺ T cell immunity is strongly suppressed, which is associated with cancer and other age-related diseases. The mechanism underlying this age-related decrease in immune function remains largely unknown. This study investigated the role of T cell function in age-related unresponsiveness to PD-1 blockade cancer therapy. We found inefficient generation of CD44^lowCD62L^low CD8⁺ T cell subset (P4) in draining lymph nodes of tumor-bearing aged mice. In vitro stimulation of naive CD8⁺ T cells first generated P4 cells, followed by effector/memory T cells. The P4 cells contained a unique set of genes related to enzymes

SUBMITTER: Nakajima Y 

PROVIDER: S-EPMC8201912 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature