The spatial landscape of lung pathology during COVID-19 progression.

ABSTRACT: Recent studies have provided insights into the pathology of and immune response to COVID-19^1-8. However, a thorough investigation of the interplay between infected cells and the immune system at sites of infection has been lacking. Here we use high-parameter imaging mass cytometry⁹ that targets the expression of 36 proteins to investigate the cellular composition and spatial architecture of acute lung injury in humans (including injuries derived from SARS-CoV-2 infection) at single-cell resolution. These spatially resolved single-cell data unravel the disordered structure of the infected and injured lung, alongside the distribution of extensive immune infiltration. Neutrophil and macrophage infiltration are hallmarks of bacterial pneumonia and COVID-19, respectively.

SUBMITTER: Rendeiro AF 

PROVIDER: S-EPMC8204801 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature