Regulatory KIR⁺ RA⁺ T cells accumulate with age and are highly activated during viral respiratory disease.

ABSTRACT: Severe respiratory viral infectious diseases such as influenza and COVID-19 especially affect the older population. This is partly ascribed to diminished CD8⁺ T-cell responses a result of aging. The phenotypical diversity of the CD8⁺ T-cell population has made it difficult to identify the impact of aging on CD8⁺ T-cell subsets associated with diminished CD8⁺ T-cell responses. Here we identify a novel human CD8⁺ T-cell subset characterized by expression of Killer-cell Immunoglobulin-like Receptors (KIR⁺ ) and CD45RA (RA⁺ ). These KIR⁺ RA⁺ T cells accumulated with age in the blood of healthy individuals (20-82 years of age, n = 50), expressed high levels of aging-related markers of T-cell regul

SUBMITTER: Pieren DKJ 

PROVIDER: S-EPMC8208794 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature