Macrophage activation in stellate ganglia contributes to lung injury-induced arrhythmogenesis in male rats.

ABSTRACT:

Aim

Patients suffering from acute lung injury (ALI) are at high risk of developing cardiac arrhythmias. We hypothesized that stellate ganglia (SG) neural inflammation contributes to ALI-induced arrhythmia.

Methods

We created an ALI rat model using a single tracheal instillation of bleomycin (2.5 mg/kg), with saline as a sham control. We recorded ECGs by implanted radiotelemetry in male bleomycin and sham rats treated with and without oral minocycline (20 mg/kg/d), an anti-inflammatory drug that inhibits microglia/macrophage activation. The SG neuronal excitability was assessed by electrophysiology experiments.

Results

ECG data showed that bleomycin-exposed rats exhibited significantly more spontaneous premature ventricular contractions (PVCs) from 1- to 3-week post-in

SUBMITTER: Hong J 

PROVIDER: S-EPMC8212166 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature