Engineering Protease-Resistant Peptides to Inhibit Human Parainfluenza Viral Respiratory Infection.

ABSTRACT: The lower respiratory tract infections affecting children worldwide are in large part caused by the parainfluenza viruses (HPIVs), particularly HPIV3, along with human metapneumovirus and respiratory syncytial virus, enveloped negative-strand RNA viruses. There are no vaccines for these important human pathogens, and existing treatments have limited or no efficacy. Infection by HPIV is initiated by viral glycoprotein-mediated fusion between viral and host cell membranes. A viral fusion protein (F), once activated in proximity to a target cell, undergoes a series of conformational changes that first extend the trimer subunits to allow insertion of the hydrophobic domains into the target cell membrane and then refold the trimer into a stable postfusion state, driving the merger of the viral

SUBMITTER: Outlaw VK 

PROVIDER: S-EPMC8215719 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature