Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs.

ABSTRACT:

Background

Mast cell and basophil activation by antigen cross-linking of FcεRI-bound IgE is central to allergy pathogenesis. We previously demonstrated global suppression of this process by rapid desensitization with anti-FcεRIα mAbs.

Objectives

We sought to determine whether use of monovalent (mv) anti-FcεRIα mAbs increases desensitization safety without loss of efficacy.

Methods

mv anti-human (hu) FcεRIα mAbs were produced with mouse-derived immunoglobulin variable regions and huIgG₁ or huIgG₄ C regions and were used to suppress murine IgE-mediated anaphylaxis and food allergy. mAbs were administered as a single dose or as serially increasing doses to mice that express hu instead of mouse FcεRIα; mice that additionally have an allergy-promoting

SUBMITTER: Khodoun MV 

PROVIDER: S-EPMC8215870 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature