Genetic engineering of T cells for immunotherapy.
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ABSTRACT:
SUBMITTER: Ellis GI
PROVIDER: S-EPMC8217325 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic engineering of T cells for immunotherapy.
Ellis Gavin I GI Sheppard Neil C NC Riley James L JL
Nature reviews. Genetics 20210218 7
Genetically engineered T cell immunotherapies have provided remarkable clinical success to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill cancer, and these approaches have the potential to provide therapeutic benefit for numerous other cancers, infectious diseases and autoimmunity. By introduction of either a transgenic T cell receptor or a chimeric antigen receptor, T cells can be programmed to target cancer cells. However, initial studies have made it ...[more]
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