The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome.

ABSTRACT:

Background

Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5-HT₃ receptor antagonists to reduce nausea has been described for chemotherapy, but not for nausea secondary to vestibular disorders.

Methods

Sixteen dogs with vestibular syndrome-associated nausea were included in the open-label, multicentre study. The intensity of nausea-like behaviour was analysed before ondansetron administration (0.5 mg/kg i.v.) and 2 h afterwards, using a validated 5-point-scale. The occurrence and frequency of salivation, lip licking, restlessness, vocalisation, lethargy, and vomiting were assessed.

Results

All dogs initially showed signs of nausea, whereas onl

SUBMITTER: Foth S 

PROVIDER: S-EPMC8218477 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature