Heparanase expression and activity are increased in platelets during clinical sepsis.

ABSTRACT:

Background

Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx, and maintain physiological barriers between the blood and endothelial cells. HPSE increases during sepsis, which contributes to injurious glyocalyx degradation, loss of endothelial barrier function, and mortality.

Objectives

As platelets are one of the most abundant cellular sources of HPSE, we sought to determine whether HPSE expression and activity increases in human platelets during clinical sepsis. We also examined associations between platelet HPSE expression and clinical outcomes.

Patients/methods

Expression and activity of HPSE was determined in platelets isolated from septic patients (n = 59

SUBMITTER: Eustes AS 

PROVIDER: S-EPMC8218538 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature