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Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation.

ABSTRACT: 1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a-h and glycine alkyl esters 2a-c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa-ea in good yields. The γ-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin, and kidney cancer cells.

SUBMITTER: Dudhe P

PROVIDER: S-EPMC8218543 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation.

Dudhe Premansh P Krishnan Mena Asha MA Yadav Kratika K Roy Diptendu D Venkatasubbaiah Krishnan K Pathak Biswarup B Chelvam Venkatesh V

Beilstein journal of organic chemistry 20210617

1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a-h and glycine alkyl esters 2a-c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa-ea in good yields. The γ-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin, and kidney cancer cells. ...[more]

PMID: 34221174

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