Increased frequency of TIGIT⁺CD73-CD8⁺ T cells with a TOX⁺ TCF-1low profile in patients with newly diagnosed and relapsed AML.

ABSTRACT: The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML) and will help to identify potential therapeutic targets.  The phenotype and expression of transcription factors was assessed on different T-cell populations derived from peripheral blood (PB, n = 38) and bone marrow (BM, n = 43). PB and BM from patients with AML diagnosis, in remission and at relapse were compared with PB from healthy volunteers (HD) (n = 12) using multiparameter flow cytometry. An increased frequency of terminally differentiated (CD45R^-CCR7^-)CD8⁺ T cells was detected in

SUBMITTER: Brauneck F 

PROVIDER: S-EPMC8218695 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature