Hydrogen Sulfide Attenuated Sepsis-Induced Myocardial Dysfunction Through TLR4 Pathway and Endoplasmic Reticulum Stress.

ABSTRACT: Aims: We examined the change in endogenous hydrogen sulfide (H₂S) production and its role in sepsis-induced myocardial dysfunction (SIMD). Results: Significant elevations in plasma cardiac troponin I (cTnI), creatine kinase (CK), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were noted in SIMD patients, whereas left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), and plasma H₂S were significantly decreased relative to those in the controls. Plasma H₂S was linearly related to LVEF and LVFS. Subsequently, an SIMD model was developed in mice by injecting lipopolysaccharide (LPS), and NaHS, an H₂S donor, was used to elucidate the pathophysiological role of H₂S. The mice showe

SUBMITTER: Chen YH 

PROVIDER: S-EPMC8220204 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature