TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure.

ABSTRACT: The molecular mechanisms underlying premature ovarian failure, which seriously impacts the physical and psychological health of patients, are not fully understood. Here, we present the role of TRDMT1 in reactive oxygen species-induced granulosa cells death, which is considered an important cause of premature ovarian failure. We found that reactive oxygen species were increased in a H₂O₂ dose-dependent manner and accompanied by the nuclear shuttling of TRDMT1, increased DNA damage and increased apoptosis of granulosa cells. In addition, reactive oxygen species-induced granulosa cells apoptosis could be prevented by the antioxidant N-acetylcysteine or overexpression of TRDMT1. Furthermore, DNA repair following reactive oxygen species induction was severely impaired/enha

SUBMITTER: Sha C 

PROVIDER: S-EPMC8221345 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature