Ontology highlight
ABSTRACT:
SUBMITTER: Ferraro GB
PROVIDER: S-EPMC8223728 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Ferraro Gino B GB Ali Ahmed A Luengo Alba A Kodack David P DP Deik Amy A Abbott Keene L KL Bezwada Divya D Blanc Landry L Prideaux Brendan B Jin Xin X Posada Jessica M JM Chen Jiang J Chin Christopher R CR Amoozgar Zohreh Z Ferreira Raphael R Chen Ivy X IX Naxerova Kamila K Ng Christopher C Westermark Anna M AM Duquette Mark M Roberge Sylvie S Lindeman Neal I NI Lyssiotis Costas A CA Nielsen Jens J Housman David E DE Duda Dan G DG Brachtel Elena E Golub Todd R TR Cantley Lewis C LC Asara John M JM Davidson Shawn M SM Fukumura Dai D Dartois Véronique A VA Clish Clary B CB Jain Rakesh K RK Vander Heiden Matthew G MG
Nature cancer 20210401 4
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here, we assessed how metabolism differs between breast tumors in brain versus ext ...[more]