Promotion of corticospinal tract growth by KLF6 requires an injury stimulus and occurs within four weeks of treatment.

ABSTRACT: Axons in the corticospinal tract (CST) display a limited capacity for compensatory sprouting after partial spinal injuries, potentially limiting functional recovery. Forced expression of a developmentally expressed transcription factor, Krüppel-like factor 6 (KLF6), enhances axon sprouting by adult CST neurons. Here, using a pyramidotomy model of injury in adult mice, we confirm KLF6's pro-sprouting properties in spared corticospinal tract neurons and show that this effect depends on an injury stimulus. In addition, we probed the time course of KLF6-triggered sprouting of CST axons and demonstrate a significant enhancement of growth within four weeks of treatment. Finally, we tested whether KLF6-induced sprouting was accompanied by improvements in forelimb function, either singly or when c

SUBMITTER: Kramer AA 

PROVIDER: S-EPMC8224817 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature