Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells.
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ABSTRACT:
SUBMITTER: Wei L
PROVIDER: S-EPMC8228430 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells.
Wei Lengyun L Lu Xuyang X Weng Shengmei S Zhu Shenglong S Chen Yongquan Y
Biomolecules 20210608 6
The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data s ...[more]
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