Efficacy and safety of remdesivir in COVID-19 caused by SARS-CoV-2: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Evaluation of remdesivir, an RNA polymerase inhibitor, for effectiveness in adults with COVID-19.

Data sources

Electronic search for eligible articles of PubMed, Cochrane Central and clinicaltrials.gov was performed on 20 September 2020.

Participants and study eligibility criteria

Only randomised controlled trials (RCTs) evaluating efficacy of remdesivir in COVID-19 were included for meta-analysis.

Interventions

Remdesivir was compared with standard of care.

Primary and secondary outcomes

Primary outcome was mortality and secondary outcomes were time to clinical improvement and safety outcomes like serious adverse events, respiratory failure.

Study appraisal and synthesis methods

Data synthesis was done with Cochrane review manager 5 (R

SUBMITTER: Singh S 

PROVIDER: S-EPMC8228818 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature