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Finding a Balance in the Vaginal Microbiome: How Do We Treat and Prevent the Occurrence of Bacterial Vaginosis?


ABSTRACT: Bacterial vaginosis (BV) has been reported in one-third of women worldwide at different life stages, due to the complex balance in the ecology of the vaginal microbiota. It is a common cause of abnormal vaginal discharge and is associated with other health issues. Since the first description of anaerobic microbes associated with BV like Gardnerella vaginalis in the 1950s, researchers have stepped up the game by incorporating advanced molecular tools to monitor and evaluate the extent of dysbiosis within the vaginal microbiome, particularly on how specific microbial population changes compared to a healthy state. Moreover, treatment failure and BV recurrence rate remain high despite the standard antibiotic treatment. Consequently, researchers have been probing into alternative or adjunct treatments, including probiotics or even vaginal microbiota transplants, to ensure successful treatment outcomes and reduce the colonization by pathogenic microbes of the female reproductive tract. The current review summarizes the latest findings in probiotics use for BV and explores the potential of vaginal microbiota transplants in restoring vaginal health.

SUBMITTER: Joseph RJ 

PROVIDER: S-EPMC8232816 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Finding a Balance in the Vaginal Microbiome: How Do We Treat and Prevent the Occurrence of Bacterial Vaginosis?

Joseph Rebecca Jane RJ   Ser Hooi-Leng HL   Kuai Yi-He YH   Tan Loh Teng-Hern LT   Arasoo Valliammai Jayanthi Thirunavuk VJT   Letchumanan Vengadesh V   Wang Lijing L   Pusparajah Priyia P   Goh Bey-Hing BH   Ab Mutalib Nurul-Syakima NS   Chan Kok-Gan KG   Lee Learn-Han LH  

Antibiotics (Basel, Switzerland) 20210615 6


Bacterial vaginosis (BV) has been reported in one-third of women worldwide at different life stages, due to the complex balance in the ecology of the vaginal microbiota. It is a common cause of abnormal vaginal discharge and is associated with other health issues. Since the first description of anaerobic microbes associated with BV like <i>Gardnerella vaginalis</i> in the 1950s, researchers have stepped up the game by incorporating advanced molecular tools to monitor and evaluate the extent of d  ...[more]

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