Ontology highlight
ABSTRACT:
SUBMITTER: Pandey M
PROVIDER: S-EPMC8233039 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Pandey Manish M Bansal Sakshi S Bar Sudipta S Yadav Amit Kumar AK Sokol Nicholas S NS Tennessen Jason M JM Kapahi Pankaj P Chawla Geetanjali G
eLife 20210608
Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they modulate lifespan and the tissue-specific role of miRNA-mediated networks in DR-dependent enhancement of lifespan remains largely unexplored. We show that two neuronally enriched and highly conserved microRNAs, <i>miR-125</i> and <i>let-7</i> mediat ...[more]