<i>miR-125-chinmo</i> pathway regulates dietary restriction-dependent enhancement of lifespan in <i>Drosophila</i>.

ABSTRACT: Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they modulate lifespan and the tissue-specific role of miRNA-mediated networks in DR-dependent enhancement of lifespan remains largely unexplored. We show that two neuronally enriched and highly conserved microRNAs, miR-125 and let-7 mediate the DR response in Drosophila melanogaster. Functional characterization of miR-125 demonstrates its role in neurons while its target chinmo acts both in neurons and the fat body to modulate fat metabolism and longevity. Proteomic analysis revealed that Chinmo exerts its DR eff

SUBMITTER: Pandey M 

PROVIDER: S-EPMC8233039 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature