Ceramide expression in relation to breast cancer molecular subtypes in Saudi women.

ABSTRACT:

Background/introduction

Despite advances in the diagnosis and management of breast cancer (BC), it is still associated with high mortality rates. New biomarkers are being developed for the diagnosis, treatment, and prediction of responses of BC. Ceramide (CER), a bioactive sphingolipid, has emerged recently as a useful diagnostic tool in several types of tumors. In this study, we evaluated CER expression in invasive BC and assessed its relation to the molecular subtypes of BC.

Materials and methods

The clinical data and histopathological slides of 50 patients with invasive ductal carcinoma were retrieved and reviewed. The cases were then stained with a mouse monoclonal anti-ceramide antibody. Pearson correlation was used to assess the correlation between CER percentage and i

SUBMITTER: Almomen A 

PROVIDER: S-EPMC8233535 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature