Diagnostic and prognostic performance of CSF α-synuclein in prion disease in the context of rapidly progressive dementia.

ABSTRACT:

Introduction

Surrogate cerebrospinal fluid (CSF) biomarkers of neurodegeneration still have a central role in the first-line screening of patients with suspected Creutzfeldt-Jakob disease (CJD). Recently, CSF α-synuclein, a marker of synaptic damage, showed a close to optimal performance in distinguishing between CJD and other neurodegenerative dementias.

Methods

We evaluated the diagnostic value of CSF α-synuclein in patients with prion disease, non-prion rapidly progressive dementias, and non-neurodegenerative controls. Additionally, we studied its distribution across the different prion disease subtypes and evaluated its association with survival.

Results

CSF α-synuclein levels were significantly higher in patients with prion disease than in the other groups but sh

SUBMITTER: Mastrangelo A 

PROVIDER: S-EPMC8240124 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature