Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study.

ABSTRACT:

Aim

To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.

Materials and methods

Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with ¹³ C-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (¹³ C-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.

Results

We found (a

SUBMITTER: Wolnerhanssen BK 

PROVIDER: S-EPMC8247993 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature