A Simple Biomimetic Receptor Selectively Recognizing the GlcNAc₂ Disaccharide in Water.

ABSTRACT: GlcNAc₂ is the core disaccharide fragment present in N-glycans exposed on the surface of enveloped viruses of high health concern, such as coronaviruses. Because N-glycans are directly involved in the docking of viruses to host cells, recognition of GlcNAc₂ by a biomimetic receptor may be a convenient alternative to the use of lectins to interfere with viral entry and infection. Herein, we describe a simple biomimetic receptor recognizing the methyl-β-glycoside of GlcNAc₂ in water with an unprecedented affinity of 160 μM, exceeding that of more structurally complex receptors reported in the literature. The tweezers-shaped acyclic structure exhibits marked selectivity among structurally related disaccharides, and complete discrimination between mono- and dis

SUBMITTER: Francesconi O 

PROVIDER: S-EPMC8252438 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature