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Enantioselective Synthesis of α-Aryl-β2 -Amino-Esters by Cooperative Isothiourea and Bronsted Acid Catalysis.

ABSTRACT: The synthesis of α-aryl-β2 -amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94 % yield and 96:4 er), with applications to the synthesis of (S)-Venlafaxine⋅HCl and (S)-Nakinadine B. Mechanistic studies are consistent with a C(1)-ammonium enolate pathway being followed rather than an alternative dynamic kinetic resolution process. Control studies indicate that (i) a linear effect between catalyst and product er is observed; (ii) an acyl ammonium ion can be used as a precatalyst; (iii) reversible isothiourea addition to an in situ generated iminium ion leads to an off-cycle intermediate that can be used as a productive precatalyst.

SUBMITTER: Zhao F 

PROVIDER: S-EPMC8252622 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Enantioselective Synthesis of α-Aryl-β<sup>2</sup> -Amino-Esters by Cooperative Isothiourea and Brønsted Acid Catalysis.

Zhao Feng F   Shu Chang C   Young Claire M CM   Carpenter-Warren Cameron C   Slawin Alexandra M Z AMZ   Smith Andrew D AD  

Angewandte Chemie (International ed. in English) 20210504 21

The synthesis of α-aryl-β<sup>2</sup> -amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94 % yield and 96:4 er), with applications to the synthesis of (S)-Venlafaxine⋅HCl and (S)-Nakinadine B. Mechanistic studies are consistent with a C(1)-ammonium enolate pathway being followed  ...[more]

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