Ontology highlight
ABSTRACT:
SUBMITTER: Introvigne ML
PROVIDER: S-EPMC8256004 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Introvigne Maria Luisa ML Taracila Magdalena A MA Prati Fabio F Caselli Emilia E Bonomo Robert A RA
ChemMedChem 20200622 14
Boronic acids are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific boronates bearing an amide side chain that mimics the β-lactam's amide side chain have been advanced in several studies. Herein, we describe a new class of boronic acids in which the amide group is replaced by a bioisostere triazole. The boronic acids were obtained in a two-step synthesis that relies on the solid and versatile copper-catalyzed azide-alkyne cycloaddition (Cu ...[more]