Exploring the Complexity of Death-Censored Kidney Allograft Failure.

ABSTRACT:

Background

Few studies have thoroughly investigated the causes of kidney graft loss (GL), despite its importance.

Methods

A novel approach assigns each persistent and relevant decline in renal function over the lifetime of a renal allograft to a standardized category, hypothesizing that singular or multiple events finally lead to GL. An adjudication committee of three physicians retrospectively evaluated indication biopsies, laboratory testing, and medical history of all 303 GLs among all 1642 recipients of transplants between January 1, 1997 and December 31, 2017 at a large university hospital to assign primary and/or secondary causes of GL.

Results

In 51.2% of the patients, more than one cause contributed to GL. The most frequent primary or secondary causes leading

SUBMITTER: Mayrdorfer M 

PROVIDER: S-EPMC8259637 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature