Has programmed cell death ligand-1 MET an accomplice in non-small cell lung cancer?-a narrative review.

ABSTRACT: Recently approved and highly specific small-molecule inhibitors of c-MET exon 14 skipping mutations (e.g., capmatinib, tepotinib) are a new and important therapeutic option for the treatment of non-small cell lung cancer (NSCLC) patients harbouring c-MET alterations. Several experimental studies have provided compelling evidence that c-MET is involved in the regulation of the immune response by up-regulating inhibitory molecules (e.g., PD-L1) and down-regulating of immune stimulators (e.g., CD137, CD252, CD70, etc.). In addition, c-MET was found to be implicated in the regulation of the inflamed tumour microenvironment (TME) and thereby contributing to an increased immune escape of tumour cells from T cell killing. Moreover, it is a major resistance mechanism following treatment of epiderm

SUBMITTER: Dempke WCM 

PROVIDER: S-EPMC8264346 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature