Collagen sponge prolongs taurine release for improved wound healing through inflammation inhibition and proliferation stimulation.

ABSTRACT:

Background

Attenuating oxidative stress response is an effective strategy for the treatment of wounds. Taurine is a widely abundant amino acid in mammal species, capable of inhibiting oxygen-free radicals during the inflammation phase.

Methods

A novel taurine carried biocompatible composite collagen-derived sponge, Tau@Col, was fabricated for the treatment of a full-thickness removal mouse wounds model. In vitro experiments included taurine release from Tau@Col and cell viability when co-cultured with Tau@Col. With the prolonged release of taurine upon the wound site, Tau@Col was engineered to perform well in the wound site through inflammation inhibition and proliferation stimulation as demonstrated by a series of histological staining.

Results

In vitro

SUBMITTER: Wu L 

PROVIDER: S-EPMC8267268 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature