A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection.

ABSTRACT: Background: Catheter-associated urinary tract infection (CAUTI) is a frequent community-acquired infection and the most common nosocomial infection. Here, we developed a novel antimicrobial catheter concept that utilizes a silicone-based interpenetrating polymer network (IPN) as balloon material to facilitate a topical slow-release prophylaxis of antibacterial agents across the balloon to the urinary bladder. Methods: The balloon material was achieved by modifying low shore hardness silicone tubes with a hydrogel interpenetrating polymer in supercritical CO₂ using the sequential method. Release properties and antibacterial efficacy of the IPN balloon treatment concept was investigated in vitro and in a porcine CAUTI model developed for the study. In the latt

SUBMITTER: Stærk K 

PROVIDER: S-EPMC8267894 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature