Cell encapsulated and microenvironment modulating microbeads containing alginate hydrogel system for bone tissue engineering.

ABSTRACT: Functional tissue regeneration using synthetic biomaterials requires proliferation and heterotypic differentiation of stem/progenitor cells within a specialized heterogeneous (biophysical-biochemical) microenvironment. The current techniques have limitations to develop synthetic hydrogels, mimicking native extracellular matrix porosity along with heterogeneous microenvironmental cues of matrix mechanics, degradability, microstructure and cell-cell interactions. Here, we have developed a microenvironment modulating system to fabricate in situ porous hydrogel matrix with two or more distinct tailored microenvironmental niches within microbeads and the hydrogel matrix for multicellular tissue regeneration. Electrosprayed pectin-gelatin blended microbeads and crosslinked alginate hydrogel syst

SUBMITTER: Veernala I 

PROVIDER: S-EPMC8271062 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature