Plasma levels of soluble TGF ß receptor type III: no apparent promise as a marker in acute pancreatitis.

ABSTRACT:

Aim

To assess the potential of the soluble transforming growth factor β receptor type III (sTGFβrIII), a key regulator in TGFβ signaling, as a biomarker for diagnosis and stratification of patients with acute pancreatitis (AP).

Methods

In this small prospective pilot study, patients' (N=22) plasma samples were obtained at three time points: the first and fourth day of hospitalization and the day of hospital discharge. Healthy controls' plasma (N=25) was obtained at a single time point. Concentration of sTGFβrIII in plasma was determined by ELISA. Data were analyzed by fitting linear or linear mixed models.

Results

Plasma sTGFβrIII levels at presentation (day 1) were similar in AP patients and healthy participants, irrespectively of the disease severity. sTGFβrIII leve

SUBMITTER: Salai G 

PROVIDER: S-EPMC8275940 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature