Genomic heterogeneity and copy number variant burden are associated with poor recurrence-free survival and 11q loss in human papillomavirus-positive squamous cell carcinoma of the oropharynx.

ABSTRACT:

Background

Human papillomavirus-positive (HPV+) squamous cell carcinoma of the oropharynx (OPSCC) is the most prevalent HPV-associated malignancy in the United States. Favorable treatment outcomes have led to increased interest in treatment de-escalation to reduce treatment morbidity as well as the development of prognostic markers to identify appropriately low-risk patients. Intratumoral genomic heterogeneity and copy number alteration burden have been demonstrated to be predictive of poor outcomes in many other cancers; therefore, we sought to determine whether intratumor heterogeneity and genomic instability are associated with poor outcomes in HPV+ OPSCC.

Methods

Tumor heterogeneity estimates were made based on targeted exome sequencing of 45 patients with HPV+ OPSCC tum

SUBMITTER: Schrank TP 

PROVIDER: S-EPMC8277690 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature