A zebrafish-centric approach to antiepileptic drug development.
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ABSTRACT:
SUBMITTER: Baraban SC
PROVIDER: S-EPMC8277967 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
A zebrafish-centric approach to antiepileptic drug development.
Disease models & mechanisms 20210707 7
Danio rerio (zebrafish) are a powerful experimental model for genetic and developmental studies. Adaptation of zebrafish to study seizures was initially established using the common convulsant agent pentylenetetrazole (PTZ). Larval PTZ-exposed zebrafish exhibit clear behavioral convulsions and abnormal electrographic activity, reminiscent of interictal and ictal epileptiform discharge. By using this model, our laboratory developed simple locomotion-based and electrophysiological assays to monito ...[more]
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