Outcomes of stereotactic radiosurgery for large vestibular schwannomas: a systematic review and meta-analysis.

ABSTRACT:

Background

Large vestibular schwannomas (VS) pose a treatment challenge for both microsurgery (MS) and stereotactic radiosurgery (SRS). Technical developments have allowed for safer irradiation of large tumors. It remains unclear if SRS can achieve appropriate tumor control and acceptable cranial nerve toxicities. In this study, we assess outcomes of irradiation for large VS.

Methods

PubMed MEDLINE, EMBASE, Web of Science, and Cochrane were searched for all the studies assessing SRS outcome in large VS. Primary endpoints included clinical and radiographic tumor control, need for salvage surgery, serviceable hearing, cranial nerve V and VII impairment, presence of hydrocephalus requiring shunting, and presence of vertigo/dizziness.

Results

Twenty-two studies were ident

SUBMITTER: Tosi U 

PROVIDER: S-EPMC8278356 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature