The dioxasilepanyl group as a versatile organometallic unit: studies on stability, reactivity, and utility.

ABSTRACT: Organic synthesis is performed based on precise choices of functional groups and reactions employed. In a multistep synthesis, an ideal functional group should be compatible with various reaction conditions and unaltered until it is subjected to a selective conversion. The current study was set out to search for a silicon functionality that meets these criteria. Here we have established a new silicon-based synthetic methodology centred on a bulky 7-membered dialkoxysilyl group (2,4,4,7,7-pentamethyl-1,3,2-dioxasilepan-2-yl) that uniquely has both stability and on-demand reactivity. The exceptional stability of this functional group was corroborated by both experimental and computational studies which demonstrated that key factors for its stability were a 7-membered structure and steric hin

SUBMITTER: Saito H 

PROVIDER: S-EPMC8278973 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature