25-OHD response to vitamin D supplementation in children: effect of dose but not GC haplotype.

ABSTRACT:

Objective

GC/DBP effects on response to vitamin D supplementation have not been well-studied. Thus we assessed free and total 25-OHD after vitamin D treatment across the six common GC haplotypes.

Design

This double-blind, randomized study compared two vitamin D3 doses in healthy, urban-dwelling 6-month to 10-year-old children at-risk for vitamin D deficiency. Randomization was stratified by GC haplotype.

Methods

Children were randomized to receive 2800 or 7000 International Units of vitamin D3 weekly. 25-OHD and 1,25(OH)2D were sampled at baseline and after 1-6 months of supplementation.

Results and conclusions

One hundred ninety-two of 225 enrolled subjects completed the study. After one month, total 25-OHD increased with both doses and were higher with 7000 I

SUBMITTER: Simpson CA 

PROVIDER: S-EPMC8284876 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature