Oxygen-Sensitive MRI: A Predictive Imaging Biomarker for Tumor Radiation Response?

ABSTRACT:

Purpose

To develop a noninvasive prognostic imaging biomarker related to hypoxia to predict SABR tumor control.

Methods and materials

A total of 145 subcutaneous syngeneic Dunning prostate R3327-AT1 rat tumors were focally irradiated once using cone beam computed tomography guidance on a small animal irradiator at 225 kV. Various doses in the range of 0 to 100 Gy were administered, while rats breathed air or oxygen, and tumor control was assessed up to 200 days. Oxygen-sensitive magnetic resonance imaging (MRI) (T₁-weighted, ΔR₁, ΔR₂*) was applied to 79 of these tumors at 4.7 T to assess response to an oxygen gas breathing challenge on the day before irradiation as a probe of tumor hypoxia.

Results

Increasing radiation dose in the rang

SUBMITTER: Arai TJ 

PROVIDER: S-EPMC8286313 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature