Precision omics data integration and analysis with interoperable ontologies and their application for COVID-19 research.

ABSTRACT: Omics technologies are widely used in biomedical research. Precision medicine focuses on individual-level disease treatment and prevention. Here, we propose the usage of the term 'precision omics' to represent the combinatorial strategy that applies omics to translate large-scale molecular omics data for precision disease understanding and accurate disease diagnosis, treatment and prevention. Given the complexity of both omics and precision medicine, precision omics requires standardized representation and integration of heterogeneous data types. Ontology has emerged as an important artificial intelligence component to become critical for standard data and metadata representation, standardization and integration. To support precision omics, we propose a precision omics ontology hypothesis,

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8287950 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature