Liftoff: accurate mapping of gene annotations.

ABSTRACT:

Motivation

Improvements in DNA sequencing technology and computational methods have led to a substantial increase in the creation of high-quality genome assemblies of many species. To understand the biology of these genomes, annotation of gene features and other functional elements is essential; however, for most species, only the reference genome is well-annotated.

Results

One strategy to annotate new or improved genome assemblies is to map or 'lift over' the genes from a previously annotated reference genome. Here, we describe Liftoff, a new genome annotation lift-over tool capable of mapping genes between two assemblies of the same or closely related species. Liftoff aligns genes from a reference genome to a target genome and finds the mapping that maximizes sequence iden

SUBMITTER: Shumate A 

PROVIDER: S-EPMC8289374 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature