Characterization of the Striatal Extracellular Matrix in a Mouse Model of Parkinson's Disease.

ABSTRACT: Parkinson's disease's etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has been neglected. The chemical modifications that might accumulate in matrix components due to their long half-live and the low amount of extracellular antioxidants could also contribute to the disease and explain ineffective cellular therapies. The enriched striatal extracellular matrix from a mouse model of Parkinson's disease was characterized by Raman spectroscopy. We found a matrix fingerprint of increased oxalate content and oxidative modifications. To uncover the effects of these changes

SUBMITTER: Freitas A 

PROVIDER: S-EPMC8301085 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature