Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography-tandem mass spectrometry-based urine analysis.

ABSTRACT:

Aims

None of the existing studies on adherence have directly measured levels of all medications (or their metabolites) in patients with heart failure (HF).

Methods and results

We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4-6 weeks after hospitalization with HF. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent, i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adh

SUBMITTER: Simpson J 

PROVIDER: S-EPMC8302254 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature