Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.

ABSTRACT:

Background

Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF).

Objectives

This study sought to evaluate whether CHIP is associated with incident HF.

Methods

CHIP status was obtained from whole exome or genome sequencing of blood DNA in participants without prevalent HF or hematological malignancy from 5 cohorts. Cox proportional hazards models were performed within each cohort, adjusting for demographic and clinical risk factors, followed by fixed-effect meta-analyses. Large CHIP clones (defined as variant allele frequency >10%), HF wi

SUBMITTER: Yu B 

PROVIDER: S-EPMC8313294 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature