Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.
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ABSTRACT:
SUBMITTER: Leslie JL
PROVIDER: S-EPMC8315233 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.
Leslie Jhansi L JL Weddle Erin E Yum Lauren K LK Lin Ye Y Jenior Matthew L ML Lee Benjamin B Ma Jennie Z JZ Kirkpatrick Beth D BD Nayak Uma U Platts-Mills James A JA Agaisse Herve F HF Haque Rashidul R Petri William A WA
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20210601 11
In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis. ...[more]
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