Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.

ABSTRACT: In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.

SUBMITTER: Leslie JL 

PROVIDER: S-EPMC8315233 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature